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Motor Behavior and Neuroplasticity Laboratory (MBNL)


The overall research goal at the Motor Behavior and Neuroplasticity Laboratory (MBNL) is to determine the brain-behavior relationship in individuals with neurological disorders and non-disabled older adults. Behaviorally, we are interested in understanding motor learning capability and cognitive functions in people with Parkinson’s disease (PD), individuals with stroke, and adults with or without cognitive impairment. One research aim at the MBNL is to incorporate motor learning concepts into neurorehabilitation to facilitate the intervention effects of physical therapy for individuals with PD and other neurological disorders.

To probe the brain-behavior relationship associated with motor learning and control, transcranial magnetic stimulation (TMS) is used in this lab. Transcranial magnetic stimulation is a non-invasive tool that enabled researchers to evaluate neuroplasticity in human brain. We use single-pulse or paired-pulse TMS to determine the changes in corticomotor excitability associated with learning, physical intervention, brain injury, or brain degeneration. Repetitive TMS (rTMS) is used in this lab to determine the role of a certain brain region in motor learning or a specific cognitive function. We also use rTMS as an adjuvant intervention approach to augment the benefits of physical therapy. 


Current Lab members

Laboratory Director: Ya-Yun Lee, PT, PhD, Assistant Professor

Research assistant: Suet-Ting Chen

Research Articles and Research Directions

Published Journal Articles:

  1. Ya-Yun Lee, Ching-Yi Wu, Ching-Hung Teng, Wen-Chuin Hsu, Ku-Chou Chang, Poyu Chen. (2016) Evolving methods to combine cognitive and physical training for individuals with mild cognitive impairment: study protocol for a randomized controlled study. Trials, 17, 526. doi: 10.1186/s13063-016-1650-4.
  2. Beth E. Fisher, Andrew Piraino, Ya-Yun Lee*, Jo A. Smith, Sean Johnson, Todd E. Davenport, Kornelia Kulig. (2016) The effect of velocity of joint mobilization on corticospinal excitability in individuals with a history of ankle sprain. Journal of Orthopaedic & Sports Physical Therapy, 46, 562-570. doi:10.2519/jospt.2016.6602
  3. Ya-Yun Lee, Carolee J. Winstein, Beth E. Fisher. (2016) Role of the dorsolateral prefrontal cortex in context-dependent motor performance. European Journal of Neuroscience, 43, 954-960. doi: 10.1111/ejn.13178.
  4. Ya-Yun Lee*, Carolee J. Winstein, James Gordon, Giselle Petzinger, Elizabeth Zelinski, Beth E. Fisher. (2016) Context-dependent learning in people with Parkinson’s disease. Journal of Motor Behavior, 48, 240-248. doi: 10.1080/00222895.2015.1082964.
  5. Ya-Yun Lee, Keh-Chung Lin, Hsiao-Ju Cheng, Ching-Yi Wu, Yu-Wei Hsieh, Chih-Kuang Chen. (2015) Effects of combined robot-assisted therapy with neuromuscular electrical stimulation on motor impairment, motor and daily function, and quality of life in patients with chronic stroke: A double-blinded randomized controlled trial. Journal of NeuroEngineering and Rehabilitation, 12, 96. doi: 10.1186/s12984-015-0088-3.
  6. Ya-Yun Lee†, Yu-Wei Hsieh†, Ching-Yi Wu, Keh-Chung Lin, Chih-Kuang Chen. (2015) Proximal Fugl-Meyer Assessment scores predict clinically important upper limb improvement after 3 stroke rehabilitative interventions. Archives of Physical Medicine and Rehabilitation, 96, 2137-2144. doi: 10.1016/j.apmr.2015.07.019.
  7. Ya-Yun Lee†, Keh-Chung Lin†, Ching-Yi Wu, Ching-Hua Liao, Jui-Chi Lin, Chia-Ling Chen. (2015) Combining afferent stimulation and mirror therapy for improving muscular, sensorimotor, and daily functions after stroke – A randomized, placebo-controlled study. American Journal of Physical Medicine & Rehabilitation, 94, 859-868. doi: 10.1097/PHM.0000000000000271.

Ongoing Project:

  1. Understand freezing of gait in Parkinson’s disease: behavioral physiology and clinical application. (MOST: 105-2314-B-002-202)


  1. Transcranial magnetic stimulation
  2. Neurobehavioral systems
  3. Biopac MP150


Contact information

Ya-Yun Lee, PT, PhD  Assistant Professor

Address: Floor 3, No.17, Xuzhou Rd., Zhongzheng Dist., Taipei City 100, Taiwan (R.O.C.)

Tel: +886-2-33668155

Fax: +886-2-33668161

Email: yayunlee@ntu.edu.tw

Last Updated: 2017/2/17 下午 03:47:02

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