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The Mechanobiology Lab

About Us

Welcome to the Mechanobiology Lab of School and Graduate Institute of Physical Therapy, National Taiwan University. We live in exciting times. Mechanobiology is an emerging field that approaches the cells' biological responses to mechanical stresses and the mechanotransduction mechanisms by which mechanical stresses are transduced into a cascade of cellular and molecular events. The main research interests of the Mechanobiology Lab are mechanobiological models in ligamentum flavum degeneration and tendinopathy, physical agents in tendon cell metabolism and physical therapy intervention following plastic reconstruction.


Director: Yuan-Hung Chao, PhD, PT

Research assistant: Tz-Ting Zheng

Research Direction


  1. Wang RY, Wang YL, Cheng FY, Chao YH, Chen CL, Yang YR. Effects of combined exercise on gait variability in community-dwelling older adults. Age (Dordr). 2015 Jun;37(3):9780. doi: 10.1007/s11357-015-9780-2. Epub 2015 Apr 25. PubMed PMID: 25907712. (SCI)
  2. Chen YH, Hsu CY, Lien SH, Yu SJ, Chang JM, Chao YH*.Entry into vocational rehabilitation program following work-related hand injury: potential candidates. International Journal of Occupational Medicine and Environmental Health. Accepted. (SCI)
  3. Chen MH, Huang YC, Sun JS, Chao YH, Chen MH*. Second messengers mediating the proliferation and collagen synthesis of tenocytes induced by low-level laser irradiation. Lasers in Medical Science. 2015 Jan;30(1):263-72. (SCI)
  4. Chao YH, Tsuang YH, Sun JS, Sun MG, Chen MH. Centrifugal force induces human ligamentum flavum fibroblasts inflammation through activation of JNK and p38 pathways. Connective Tissue Research 2012;53(5):422-9. (SCI)
  5. Chao YH, Yang HS, Sun MG, Sun JS, Chen MH. Elastin-derived peptides induce inflammatory responses through the activation of NF-κB in human ligamentum flavum cells. Connective Tissue Research 2012;53(5):407-14. (SCI)
  6. Chen YH, Lin HT, Lin YT, Chao YH*, Lin CH, Wei FC, Lien SH. Self-perceived health and return to work following work-related hand injury. Occupational Medicine (Lond). 2012 Jun;62(4):295-7. (SCI)
  7. Chao YH, Tsuang YH, Sun JS, Cheng CK, Chen MH. The cross-talk between transforming growth factor-beta1 and ultrasound stimulation during mechanotransduction of rat tenocytes. Connective Tissue Research 2011;52(4):313-21. (SCI)
  8. Tsuang YH, Liao LW, Chao YH, Sun JS, Cheng CK, Chen MH, Weng PW. Effects of low intensity pulsed ultrasound on rat Schwann cells metabolism. Artificial Organs. 2011 Apr;35(4):373-83. (SCI)
  9. Chao YH, Tsuang YH, Sun JS, Chen LT, Chiang YF, Wang CC, Chen MH. Effects of Shock Waves on Tenocyte Proliferation and Extracellular Matrix Metabolism. Ultrasound in Medicine and Biology 2008 May;34(5):841-52. (SCI)



  1. Molecular mechanisms of ligamentum flavum degeneration in diabetes—effects of high glucose concentration and advanced glycation end products on ligamentum flavum cell metabolism, osteogenesis and apoptosis in vitro. PI 2015/01/01- 2016/07/31 MOST 104-2314-B-002 -002 -MY2  1,700,000
  2. Rehabilitation outcomes in oral cancer after reconstructive surgery Co-PI 2015/01/01-2015/12/31 CGMH X8548


Future directions:

  1. Physical therapy intervention following plastic reconstruction
  2. Mechanobiological models in ligamentum flavum degeneration and tendinopathy
  3. Physical agents in tendon cell/stem cell metabolism

Tissue engineering and regenerative medicine in ligament and tendon 



Portable gait analysis system

Physical agents: USD, LASER, Compression model…

Portable gait analysis system

Contact us:

Floor 3, No.17, Xuzhou Rd., Zhongzheng District, Taipei City 100, Taiwan (R.O.C.)

Tel: 02-33668129

E-mail: yuanhungchao@ntu.edu.tw

Fax: 02-33668161

Last Updated: 2015/5/14 下午 04:47:10

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